Ok we didn't have Win10 already at the office but we will have a look on that problems soon.
But it's strange, because from what I understand it previously works on your system, So the problem perhaps come from the Wacom drivers.
Can your try to remove it and install it again with this process :
1. Go to Control Panel.
2. Under Hardware and Sound, access to the Wacom Tablet Properties.
3. Click on the Remove Preferences option.
4. In the Tablet Preference File Utility dialog, click on the Remove button to remove all user preferences of Wacom.
5. After doing that, click Download Driver Update under Wacom Tablet Properties to re-install the driver again.